نتایج جستجو برای: Brain-derived- neurotrophic factor

تعداد نتایج: 1678613  

Journal: :iranian journal of medical sciences 0
shahla shojaei department of clinical biochemistry, school of pharmacy and pharmaceutical sciences, isfahan university of medical sciences, isfahan, iran mohammad reza panjehshahin department of pharmacology, school of medicine, shiraz university of medical sciences, shiraz, iran; sayed mohammad shafiee department of biochemistry and recombinant protein laboratory, school of medicine, shiraz university of medical sciences, shiraz, iran; zahra khoshdel department of biochemistry and recombinant protein laboratory, school of medicine, shiraz university of medical sciences, shiraz, iran; mohammad borji department of biochemistry and recombinant protein laboratory, school of medicine, shiraz university of medical sciences, shiraz, iran; ghasem ghasempour department of biochemistry and recombinant protein laboratory, school of medicine, shiraz university of medical sciences, shiraz, iran;

background: the induction of brain-derived neurotrophic factor (bdnf) expression in the hippocampus has shown to play a role in the beneficial effects of resveratrol (rsv) on the learning and memory. the bdnf gene has a complicated structure with eight 5’ noncoding exons (i-ixa), each of which can splice to a common coding exon (ix) to form a functional transcript. estrogens increase levels of ...

Journal: :caspian journal of neurological sciences 0
parvin babaei physiology department, faculty of medicine, guilan university of medical sciences, rasht, iran ; [email protected] sanaz vahdati bahram soltani-tehrani

background: it has been known that brain-derived neurotrophic factor (bdnf) is involved in neural survival and long term memory (ltm). here we hypothesized that bdnf as a potent neurotrophic factor might modulate amnestic effect induced by morphine. objectives: the aim of this study was to examine whether infusion of exogenous bdnf in the ca1 regions of the dorsal hippocampi could ameliorate me...

Journal: :iranian journal of pharmaceutical research 0
niki vakili zahir department of pharmacology- toxicology, faculty of pharmacy, tehran university of medical sciences, tehran, iran. mousa abkhezr department of pharmacology- toxicology, faculty of pharmacy, tehran university of medical sciences, tehran, iran. zahra khaje piri department of pharmacology- toxicology, faculty of pharmacy, tehran university of medical sciences, tehran, iran. seyed nasser ostad department of pharmacology- toxicology, faculty of pharmacy, tehran university of medical sciences, tehran, iran. abbass kebriaezade department of pharmacology- toxicology, faculty of pharmacy, tehran university of medical sciences, tehran, iran. mohammad hossein ghahremani department of pharmacology- toxicology, faculty of pharmacy, tehran university of medical sciences, tehran, iran.

low glucose condition induces neuronal cell-death via intracellular mechanisms including mitogen-activated protein kinases (mapk) signaling pathways. it has been shown that low glucose medium decreases neuronal survival in cerebellar granule neurons (cgns). in this study, we have examined the activation of jnk, p38kinase and erk1/2 pathways in low glucose medium in cgns. the cgns were prepared ...

Journal: :international clinical neurosciences journal 0
reza taherian students' research office, school of medicine, shahid beheshti university of medical sciences, tehran, iran mahdi taherian department of biology, semnan university of medical sciences, semnan, iran

background and purpose: brain-derived neurotrophic factor (bdnf) is present in the hippocampus and cerebral cortex in high concentrations and has an important role in development, maintenance and regeneration of the nervous system. the aim of this study was to produce active bdnf in e.coli using transforming plasmid. methods: to construct an expression plasmid of bdnf, a gene coding for it was ...

Journal: :iranian red crescent medical journal 0
rasoul eslami faculty of physical education and sport sciences, allameh tabataba’i university, tehran, ir iran reza gharakhanlou physical education department, faculty of humanity and literature, tarbiat modares university, tehran, ir iran abdolreza kazemi neuroscience research center, institute of neuropharmacology, kerman university of medical sciences, kerman, ir iran; physical education department, faculty of humanity and literature, vali-e-asr university of rafsanjan, rafsanjan, ir iran; neuroscience research center, institute of neuropharmacology, kerman university of medical sciences, kerman, ir iran and physical education department, faculty of humanity and literature, vali-e-asr university of rafsanjan, rafsanjan, ir iran. tel: +98-9133982706 amir bahador dakhili neuroscience research center, institute of neuropharmacology, kerman university of medical sciences, kerman, ir iran ghazaleh sorkhkamanzadeh neuroscience research center, institute of neuropharmacology, kerman university of medical sciences, kerman, ir iran ayob sheikhy department of statistics, faculty of mathematics and computer, shahid bahonar university of kerman, kerman, ir iran

conclusions this study shows that bdnf and ngf expression decreases in diabetic neuropathy. however, this decrease can be reversed through endurance training. these results also indicate that endurance training may have a potential role in compensating for neurotrophin deficiency following diabetic neuropathy. objectives this experimental study was designed and carried out at the tarbiat modare...

Journal: :middle east journal of rehabilitation and health studies 0
ali rashidy-pour research center and department of physiology, school of medicine, semnan university of medical sciences, semnan, ir iran yaghoub fathollahi department of physiology, school of medical sciences, tarbiat modares university, tehran, ir iran hossein miladi-gorji research center and department of physiology, school of medicine, semnan university of medical sciences, semnan, ir iran; research center and department of physiology, school of medicine, semnan university of medical sciences, p.o. box: 35131-38111, semnan, ir iran. tel: +98-9125313069 manouchehr safari department of anatomy, school of medicine, semnan university of medical sciences, semnan, ir iran

background exposure to morphine decreases neurogenesis in the hippocampus. recent studies have shown that voluntary running decreases the severity of anxiety behaviors and cognitive deficits, and increased synaptic plasticity in morphine-dependent rats. objectives this study aimed to investigate whether the morphine dependence-induced attenuation of hippocampal neuron number in rats would be re...

Journal: :مجله علوم اعصاب شفای خاتم 0
maryam borhani-haghighi a. shefa neuroscience research center, khatam alanbia hospital, tehran, iran b. department of anatomy, tehran university of medical sciences, tehran, iran fatemeh alipour shefa neuroscience research center, khatam alanbia hospital, tehran, iran parastoo barati shefa neuroscience research center, khatam alanbia hospital, tehran, iran

post-traumatic stress disorder (ptsd) is a syndrome causing from a severe traumatic happening that leads to threatened death or injury. ptsd is associated with changes in limbic, hippocampal, and prefrontal cortical region function due to changes in synaptogenesis, dendritic modifying, and neurogenesis. changes in neuron in ptsd patients result from pathophysiological disturbances in inflammato...

Journal: :iranian journal of basic medical sciences 0
teng ruyang department of anesthesiology, the affiliated hospital of qingdao university, qingdao 266100, china zhao yang department of anesthesiology, the affiliated hospital of qingdao university, qingdao 266100, china feng wei department of anesthesiology, the affiliated hospital of qingdao university, qingdao 266100, china

objective(s): the present study aims to study the alteration of glutamatergic transmission in the dorsal horn neurons and the effect of gabapentin on oxaliplatin-induced neuropathic pain in rats. materials and methods: oxaliplatin (5 mg/kg) or saline was administered to adult male sprague-dawley rats.  gabapentin (60 mg/kg, ip) or vehicle was injected daily. mechanical allodynia was assessed us...

Journal: :مجله علوم اعصاب شفای خاتم 0
ali jahanbazi jahan-abad shefa neuroscience research center, khatam alanbia hospital tehran, iran hassan hosseini ravandi shefa neuroscience research center, khatam alanbia hospital tehran, iran

long-term potentiation (ltp) is a process that certain types of synaptic stimulation lead to a long-lasting enhancement in the strength of synaptic transmission. studies in recent years indicate the importance of molecular pathways in the development of memory and learning. tropomyosin receptor kinase b (trkb) is a member of the neurotrophin receptor tyrosine kinase family, that its ligand is b...

Journal: :iranian journal of basic medical sciences 0
gulay hacioglu department of physiology, faculty of medicine, giresun university, turkey ayse senturk department of clinical biochemistry, faculty of medicine, karadeniz technical university, turkey imran ince department of clinical biochemistry, faculty of medicine, karadeniz technical university, turkey ahmet alver department of clinical biochemistry, faculty of medicine, karadeniz technical university, turkey

objective(s): exposing to stress may be associated with increased production of reactive oxygen species (ros). therefore, high level of oxidative stress may eventually give rise to accumulation of oxidative damage and development of numerous neurodegenerative diseases. it has been presented that brain-derived neurotrophic factor (bdnf) supports neurons against various neurodegenerative conditio...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید